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Arbeitsgruppen

Als universitäre Einrichtung sind wir neben einer hochqualitativen Patientenversorgung sowie der Ausbildung der kommenden Ärztegenerationen auch der der stetigen wissenschaftlichen Weiterentwicklung unseres Fachgebietes verpflichtet. In diesem Rahmen betreiben wir umfassende Grundlagenforschung in unseren speziell eingerichteten Laboratorien. Zudem sind wir daran interessiert unsere Erkenntnisse schnell unseren Patienten zugute kommen zu lassen. Aufgrund dessen führen wir umfangreiche eigene klinische Studien in unserer Klinik durch und beteiligen uns an national als auch international wichtigen Multicenterstudien. 

 

Informieren Sie sich im Folgenden über unsere wissenschaftlichen Arbeitsgruppen und deren Projekte

Thrombozyten und Inflammation (AG Prof. Meinrad Gawaz)

Research Interest

Our research group is interested in regulation of platelet-dependent inflammation. Platelets play a critical role in mediating inflammatory reactions at site of platelet accumulation and modulate disease development and progression. At present we concentrate on platelet release factors such as chemokines (CXCL12) and other inflammatory mediators (e.g. MIF, Gremlin1) and their interaction with corresponding chemokine receptors such as CXCR4 and CXCR7. The research project is funded by the Deutsche Forschungsgemeinschaft and is incorporated in our Research Consortium Klinische Forschergruppe „Platelets-Basic Mechanisms and Translational Implications“. One of our major focus is Translational Medicine and to develop novel diagnostic and therapeutic strategies.#

Wissenschaftliche Mitarbeiter

Dr. rer. nat. Mita Chatterjee

cand. Dr. rer. nat. Sandra Beck

cand. Dr. med. vet. Manuela Büttcher

cand. Dr. med. vet. Franziska Schlegel

 

Arbeitsgruppe Biosignalanalyse (AG Dr. Christian Eick)

Arbeitsgruppenleiter: Oberarzt Dr. Christian Eick

Wissenschaftliche Mitarbeiter:

Dr. Martin Duckheim

Dr. Patrick Groga-Bada

Dr. Parwez Aidery

Dr. Nina Götz

Dr. Lars Mizera

Paul Helle

Katharina Klee

   

Nichtwissenschaftliche Mitarbeiter: Studienassistentin Jane Gollub

Promotionsstudenten:

Cand. med. C. Bensch

Cand. med.  L. Kittlitz

Cand. med.  L. Kaeselitz

Cand. med.  N. Fuhrmann

Cand. med.  S. Bauer

Cand. med. S. Mannes

Cand. med. Ammr al Banna

Cand med. Marc Haefeker

 

Puplikationen

Intracellular Signaling in Cardiovascular Thrombo-Inflammatory Diseases (AG Prof. Dr. Oliver Borst)

1. Intracellular signaling in platelet activation and arterial thrombosis
Platelet adhesion to subendothelial collagen after plaque rupture results in increase
of cytosolic Ca2+ activity followed by Ca2+-dependent platelet activation, aggregation
and degranulation. Platelet activation leads to the development of acute arterial
thrombotic occlusions resulting in acute ischemic stroke or myocardial infarction. The
focus of our research group are intracellular signaling pathways in platelet activation.
Especially signaling downstream of phosphoinositide 3 kinase (PI3K) and regulation
of ion channels and transporters, which are crucial for platelet function, are
investigated. The identification of platelet signaling pathways not only has clinical
implications for diagnosis, but also for rationale drug design.

2. CXC/CX3C-dependent signaling in inflammatory cardiomyopathy (DCMi)
Inflammation of myocardium is caused by pathogens such a cardiotopic viruses and
non-pathogen-related inflammation and is associated with poor clinical prognosis
(heart failure, sudden cardiac death). Inflammatory signaling pathways are critical in
the development of DCMi. The current project focuses on the role of inflammatory
CXC/CX3C chemokines (SDF-1, CXCL16, fractalkine), their respective receptors
(CXCR4/-6/-7 and CX3CR1) and intracellular signaling in cardiomyocytes
downstream of these chemokine receptors for the pathogenesis of myocarditis/DCMi.
Identification of these mechanisms may offer novel targets and therapeutic strategies
to control the disease on an individualized basis.

3. PI3K-dependent signaling in vascular inflammation
Atherosclerosis is a chronic inflammatory disease of the arterial vessel wall. Vascular
inflammation and remodeling during atherogenesis require complex cellular signaling
in monocytes/macrophages infiltrating the vessel wall. We investigate intracellular
PI3K-dependent signaling in monocytes/macrophages migration and invasion
underlying lesion formation at early stages of atherosclerosis as well as MMP
production and plaque rupture at later stages to identify novel targets in prevention
and treatment of atherogenesis.

Group leader
Professor Oliver Borst, MD, FESC

Department of Cardiology & Cardiovascular Medicine
University of Tübingen
E-mail: oliver.borst@med.uni-tuebingen.de
Phone: +49 7071 29 85996

 

Members

Patrick Münzer, PhD

Postdoctoral fellow (currently Harvard Medical School Boston/MA, USA)

 

Sascha Geue

PhD student

 

Mailin-Christin Manke

PhD student

 

Roland Tegtmeyer, MD

Research associate

 

Julian Bhowmik

MD student

 

Jan-Philipp Schütte

MD student

 

Paul Potratz

MD student

 

Daniela Eissler

Technical assistant

 

Alumni

Ann-Kathrin Eyrich, MD

Sophie Mittelstädt, MSc

Antonella Russo, MSc

Malte Schaub, MD

Evi Schmid, PhD

Eva-Maria Schmidt, PhD

Alexander Tolios, MD

Syeda Tasneem Towhid, PhD

Britta Walker-Allgaier, PhD

 

Publications

 

Funding

Deutsche Forschungsgemeinschaft (DFG) Transregio Sonderforschungsbereich CRC 240 “Platelets - molecular, cellular and systemic functions under physiological and pathological conditions”

Deutsche Forschungsgemeinschaft (DFG) “CXC/CX3C chemokine receptors and PI3K-dependent signaling pathways in the pathogenesis of inflammatory cardiomyopathy (DCMi)”

Deutsche Herzstiftung

Dr. Karl Kuhn Stiftung

Fortüne research programme

 

Collaborators
Dr. Robert Ahrends, Leibniz Institute for Analytic Sciences (ISAS), Dortmund,
Germany.
Professor Leticia Quintanilla de Fend, Department of Pathology, University of
Tübingen, Germany.
Professor Johan Heemskerk, Department of Biochemistry, Cardiovascular Research
Institute Maastricht (CARIM), Maastricht University, 6200 MD Maastricht, The
Netherlands.
Professor Christoph Kleinschnitz, Department of Neurology, University of Essen,
Germany.
Professor Karin Klingel, Department of Physiology, University of Tübingen, Germany.
Professor Florian Lang, Department of Physiology, University of Tübingen, Germany.
Professor Martin Schaller, Department of Dermatology, University of Tübingen.
Professor Harald Schulze, Department of Experimental Biomedicine, Experimental
Hemostaseology, University of Würzburg, Germany.
Professor Albert Sickmann, Leibniz Institute for Analytic Sciences (ISAS), Dortmund.
Prof. Lars Zender, Department of Gastroenterology, University of Tübingen,
Germany.


Myocardial inflammation (Prof Dr. Peter Seizer)

Basic research:

- role of Cyclophilins for cardiovascular diseases

- myocardial and vascular inflammation

- platelets and platelet-monocyte interaction

- regulation of Matrix Metalloproteinases

Clinical research:

- association of inflammation and arrhythmias

- zero fluoroscopy ablation

- novel drug targets for inflammatory cardiomyopathy

The Team:

- Saskia von Ungern-Sternberg, PhD-student

- Dr. David Heinzmann, Postdoc

- Klaudia Posavec, technician

Medical students:

- Henrik Sturhan

- Christian Heck

- Moritz Nöthel

- Stefan Fuß

- Veronika Bucher

Cyclophlin A (green) in inflammatory cardiomypathy.

Cyclophlin A (green) in inflammatory cardiomypathy.

Research needs a Future – The Tübingen Research Campus

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